Precision Gene Therapy for Liver Cancer

Firstgene Life Sciences is advancing a next-generation gene therapy for hepatocellular carcinoma (HCC) – engineered for targeted delivery, maximum efficacy, and reduced side effects.

Pioneering Precision Therapies in Liver Oncology

Firstgene Life Sciences GmbH is a biotechnology company located in Mainz, Germany, and part of the Xlife Sciences portfolio. We are focused on the development of a novel gene therapy for patients with hepatocellular carcinoma (HCC) – a major unmet medical need in liver oncology. By combining scientific excellence with strategic collaboration, we aim to deliver life-changing therapies that are not only effective but also accessible.

Targeted Therapy Through Innovation

Our therapy is built on a breakthrough gene delivery platform licensed from Hovione, which enables precise steering of adeno-associated virus (AAV) vectors directly to cancerous liver cells. This specificity significantly enhances therapeutic efficacy, having the potential to reduce side effects, and enables more efficient, sustainable manufacturing – a critical advancement over current gene therapy standards. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and represents a major global health challenge. Each year, approximately 900,000 new cases are diagnosed worldwide. Despite advancements in medical research, the 5-year survival rate remains alarmingly low at just 21%. These figures underline the urgent need for more effective and targeted treatment options, particularly for patients who are diagnosed at an advanced stage or are not eligible for surgical interventions.

A Strategic Collaboration with Hovione

Our work is made possible through an exclusive technology license from Hovione, a globally recognized leader in pharmaceutical innovation. Their proprietary AAV-targeting platform is the foundation of our precision gene therapy approach and a key enabler of our progress. This collaboration empowers us to develop a therapy that’s not only scientifically robust but also scalable – supporting broad patient access in the long run.

Hovione is a Contract Development and Manufacturing Company dedicated to helping Pharmaceutical Customers bring new and off-patent drugs to market.

Contact Us

Contact & Imprint

Location: Mainz, Germany

Email: office@firstgene.de

Firstgene Life Sciences GmbH is a portfolio company of Xlife Sciences AG

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